Wir Kaufen und Verkaufen sowohl neue als auch gebrauchte Modelleisenbahnen und Modellautos aller Marken, Spurgrößen und Epochen aus privaten Sammlungen und Geschäftsauflösungen.
Wir sind ständig auf der Suche nach großen Modelleisenbahn-Sammlungen, Erbschaften und Geschäftsauflösungen. >>> diskret
Kontakt aufnehmen
As if the concern about B.1.1.7 was not big enough, the coronavirus variant now also has the mutation that enables the Brazilian and South African offshoots to partially bypass immunities. It remains to be seen whether this will also make vaccinations less effective. Mutated coronavirus variants are spreading rapidly around the world. In Europe, the Sars-CoV-2 offshoot B.1.1.7, which was first discovered in Great Britain, is currently on the advance, as it is apparently much more infectious than the virus that has prevailed up to now. Now British scientists are discovering that he has accepted the mutation E484K, which, after the South African (B.1.351), was also detected in the Brazilian (P1) variant. There is therefore a risk that the newly mutated B.1.1.7 offshoot is now also less vulnerable to antibodies. This in turn could mean that people who were previously infected can more easily become infected again. The mutation may also make vaccines less effective.
The B.1.1.7 variant with the spike protein E484K was discovered during sequencing in some samples on January 26, according to a report by the British health authority Public Health England. The data do not reveal the possible effects of the additional mutation on vaccinations. However, there is evidence that researchers at Cambridge University made tests with blood samples from 23 vaccinated people for a study on the effectiveness of the Biontech-Pfizer vaccine.
Detection of inactive cell debris Infectivity deviates from test result
One of the scientists wrote on Twitter that they generated a “pseudo-virus” in the laboratory that contained all eight known B.1.1.7 mutations plus the E484K mutation. The researchers then tested how well the sera can neutralize the artificial attackers and found that more antibodies were required for this than with the normal B.1.1.7 variant without additional mutation of the spike protein.
Biontech and Pfizer confident
However, this has not yet proven that the new variant will also limit the effect of the vaccine in reality. An artificial virus is unlikely to be synonymous with a real virus. In addition, the subjects whose blood was drawn for the study had only received the first dose three weeks earlier – so the full vaccination protection was not yet given. In addition, Biontech and Pfizer have already examined the effects of their vaccines against the Brazilian and South African variants in the laboratory using artificially generated viruses. It turned out that the neutralization of the virus with the E484K mutation was “somewhat less”, according to a joint press release by the two companies. However, this “probably does not lead to a significantly reduced effectiveness of the vaccine.”
A look behind the scenes This is how corona mutation tests work in the laboratory
The results also indicated that there is no need to develop a new vaccine against the emerging variants. Biontech and Pfizer want to continue to monitor newly emerging Sars-CoV-2 strains and continue to check the effectiveness of the vaccine in vaccinated people in order to quickly adapt their vaccine in an emergency.
“Normal” escape mutation
Specialists aren’t surprised either by E484K. Because this is probably an escape mutation that occurs when a very high infection rate or a corresponding vaccination rate leads to so-called herd immunity. A mutation takes hold which makes it possible to escape the response of the immune system’s antibody reaction. The variants with the corresponding change then displace those without this special mutation. This is obviously happening with B.1.1.7, which increases its share in the infection process very quickly. This is also shown in the report from Public Health England. At the end of October, the variant was still responsible for a very small part of the infections in Great Britain, in mid-December it was already over half of the infections, now it is more than three quarters.
Something similar can be expected in Germany, as the example of Cologne shows. They sequenced all positive cases in the past week. According to the data scientist Cornelius Roemer, B.1.1.7 has already been detected 80 times in 880 samples, which corresponds to a proportion of 9 percent. The South African variant was discovered 42 times (around 2 percent). Roemer estimates the proportion of B.1.1.7 in Germany at 5 to 15 percent, depending on the region.
You have to react to that, but there is probably no reason to panic. The falling numbers in Great Britain, Ireland and Denmark, among others, show that the mutated variants can also be brought under control with the usual measures. And if miIf the new change to B.1.1.7 should result in a significantly reduced effect of the antibodies, all is not lost.
A lockdown is not that Sweden continues to go a separate way
The body forms various antibodies, said Friedemann Weber, director of the Institute for Virology at the University of Giessen, the magazine “Spektrum”. He could therefore imagine a slight weakening of the immune response – “but there will still be enough other antibodies that can neutralize the virus.” This fits in with the results from Biontech / Pfizer. In addition, the immune system also fights the intruders with so-called T cells, which kill infected cells. Follow-up examinations of test subjects after a study by the University Hospital Tübingen had shown that even six months after an infection, these white blood cells still responded strongly to Sars-CoV-2. Weber, however, sees vector vaccines like those from Astrazeneca at an advantage because they stimulate T cells more strongly.
(Visited 1 times, 1 visits today)
Tags: suchen suche search tag anzeigen besucherzahl browser design domain inhalt jahr karpfen konto problem inhalt schalten modellbahn spielemax spiel tag webseite preise werbung
Die Regierung wollte die Pflege eigentlich für einige Jahre stabilisieren. Doch nun zeigt sich: Das Geld reicht wohl nicht mehr lange – und das Personal auch nicht. Tags: suchen suche search tag anzeigen besucherzahl browser design domain inhalt jahr karpfen konto problem inhalt schalten modellbahn spielemax spiel tag webseite preise […]
Tags: suchen suche search tag anzeigen besucherzahl browser design domain inhalt jahr karpfen konto problem inhalt schalten modellbahn spielemax spiel tag webseite preise werbung
In Aue wurden am Montag 28.4 Grad Celsius gemessen, Saharastaub könnte erneut für hohe Feinstaubwerte sorgen – unser Newsblog zur aktuellen Wetterlage. Tags: suchen suche search tag anzeigen besucherzahl browser design domain inhalt jahr karpfen konto problem inhalt schalten modellbahn spielemax spiel tag webseite preise werbung Reichsmarschall Göring hatte eine […]
Tags: suchen suche search tag anzeigen besucherzahl browser design domain inhalt jahr karpfen konto problem inhalt schalten modellbahn spielemax spiel tag webseite preise werbung
Property tax commission recommends tweaks as ballot proposal battle heats up A bipartisan group of Colorado policymakers approved nearly a dozen recommendations to soften the pinch of property tax increases Friday, including an “adjustable cap” on future hikes and mechanisms to spread out hefty tax bills. The recommendations approved by […]
Tags: suchen suche search tag anzeigen besucherzahl browser design domain inhalt jahr karpfen konto problem inhalt schalten modellbahn spielemax spiel tag webseite preise werbung
Jedoch startet der kompakte Familienfreund auch schon bei knapp 40.000 Euro. Alle Infos in der Übersicht Tags: suchen suche search tag anzeigen besucherzahl browser design domain inhalt jahr karpfen konto problem inhalt schalten modellbahn spielemax spiel tag webseite preise werbung Reichsmarschall Göring hatte eine Märklin Modelleisenbahn >>> read more
Tags: suchen suche search tag anzeigen besucherzahl browser design domain inhalt jahr karpfen konto problem inhalt schalten modellbahn spielemax spiel tag webseite preise werbung
Tags: suchen suche search tag anzeigen besucherzahl browser design domain inhalt jahr karpfen konto problem inhalt schalten modellbahn spielemax spiel tag webseite preise werbung Reichsmarschall Göring hatte eine Märklin Modelleisenbahn >>> read more
Tags: suchen suche search tag anzeigen besucherzahl browser design domain inhalt jahr karpfen konto problem inhalt schalten modellbahn spielemax spiel tag webseite preise werbung
Tags: suchen suche search tag anzeigen besucherzahl browser design domain spielemax inhalt jahr karpfen konto problem inhalt preise schalten spiel tag webseite werbung zugriff kundenkonto
BR 01, DRG
(BTTB 2120)
BR 23 1003, DR
(Zeuke 159 / 77,
545 / 77) BR 23 1111, DR
(BTTB 2110)
BR 23, DR
(BTTB, aus "Touristen Express"-Set))
br35_1111
BR 35 1111-0, DR
(BTTB 2110)
br56
BR 56 2719, DR
(BTTB 2230) G 8.2, Nr. 2721, KPEV
(BTTB 2231)
br81_013dr_zeuke_schw_rahmen br81_001rt_rahmen_plast br81_004
BR 81 013, DR
(Zeuke 159 / 51,
545 / 51) BR 81 001, DR
(BTTB 2210)
BR 81 004, DRG
(BTTB 2210)
BR 81 004, DB
(BTTB 2211)
BR 81, DR
vereinfachte Steuerung
(Zeuke 159 / 78)
br86_1615_3 br86_460
BR 86 1615-5, DR
(BTTB 2240) BR 86 460, DRG
(BTTB 2242) BR 86 173, DB
(BTTB 2241) Reihe 455, CSD
(BTTB 2244)
br 92 zeuke br 92_6582 bttb_rt_rahmen br92
BR 92 6582, DR
(Zeuke 545 / 494) BR 92 6582, DR
(BTTB 2220) BR 92 als Privatbahn (BTTB
(BTTB, aus Start-Set) BR 92 als Nord-Belge (BTTB, aus Start-Set)
start_tenderlok_schw.jpg (41542 Byte)
2achsige Tenderlok, schwarz
(BTTB, aus Start-Set) 2achsige Tenderlok, grün
(BTTB, aus Start-Set)
v36_071grau v36_071dr_gn
V 36 071, DR, grau
(Zeuke 545 / 23,
BTTB 2631) V 36 071, DR, grün
(Zeuke 545 / 22)
V 36 021, DR, grün
(BTTB 2630)
BR 103 021-2, DR, grün
(BTTB 2630)
br103gelb.jpg (62757 Byte) v36_265db_rt.jpg (56714 Byte)
BR 103 033-7, DR, gelb
(BTTB 2631) V 36 255, DB, rot
(BTTB 2632) V 36, DB, schwarz
(BTTB) Y 50, SNCF, grün
(BTTB 2634)
zeuke_v75 zeuke_t435
V 75 001, 1. Ausführung
DR, rot
(Zeuke 545 / 53) T 435 001,
1. Ausführung
CSD, blau,
weißes Geländer
(Zeuke 545 / 52)
br107_001_0 t435 t435
BR 107 001-0, DR, rot
(BTTB 2620)
T 435 001, CSD, blau
schwarzes Geländer
(BTTB 2621) T 435 040, CSD, blau
weißes Geländer
(BTTB 2621)
ym32_125
YM 32-205 , SZD, grün
(BTTB 2622) YM 32-125; SZD, grün
(BTTB 2622)
br110 br110_156 gelb br212_176_2db_rt
BR 110 034-7, DR, rot
(BTTB 2540) BR 110 156-7, DR, gelb
(BTTB 2545) BR 211 167-2, DB, blau
(BTTB 2546) BR 212 176-2, DB, rot
(BTTB 2547)
v180_146 br118_114_8
V180 160, DR
rot / elfenbein
(Zeuke 545 / 750) V 180 146, DR
rot / elfenbein
(BTTB 2520) BR 118 146-0, DR
rot / creme
(BTTB 2522) BR 118 114-8, DR
rot / creme
(BTTB 2522)
BR 119 120-4, DR
(BTTB 2521)
br130dr
BR 130 007-8, DR
(BTTB 2640) T 679, CSD
(BTTB 2641)
br221rot br221_137_3blau_beige v200ic_rt_beige_rt
V 200 139, DB
rot / grau
(Zeuke 159 / 76,
545 / 26)
BR 221 139-9, DB
rot / silbergrau
(BTTB 2510)
BR 221 137-5, DB
blau / beige
(BTTB 2511)
BR 221, DB
rot / beige
(BTTB 2512)
v200 cccp v200 silverlines
V 200 "CCCP"
silber / rot
(Zeuke ) V 200 "Silver Lines"
silber / blau
(Zeuke ) V 200
braun
(Zeuke, aus Start-Set) V 200, SJ
braun
(BTTB, aus Start-Set)
t334rt t334 t334dsb
T 334, CSD, rot
(Zeuke 545 / 502) T 334 0508, CSD, blau
(Zeuke 545 / 501) T 334, CSD, grün / weiß
(BTTB 2610) MH, DSB, grün
(Zeuke 545 / 503)
t334gn_elf_start2a
T 334, 2achsig
blau / creme
(Zeuke (, aus Start-Set) T 334, 2achsig
grün / elfenbein
(Zeuke
(BTTB, aus Start-Set)
noab_mav_neu noab_dsb_bttb noab_sncb
M 61 001, MAV, weinrot
(Zeuke 545 / 9,
BTTB 2532) M 61 019, MAV, rot
(BTTB 2532)
My 1125, DSB, weinrot
(Zeuke 545 / 8,
BTTB 2531) R 202 003, SNCB, grün
(BTTB 2533)
start_taigatrommel
2achsige Diesellok
ähnlich DR-BR 120, rot
(BTTB, aus Start-Set) 2achsige Diesellok
ähnlich DR-BR 120, grün
(BTTB, aus Start-Set)
vt2_09_dach_beige
VT 2.09.070
Dach beige
(Zeuke)
Beiwagen VB 02,
Dach beige
(Zeuke)
VT 2.09.070 + VB,
Dach grau
(Zeuke 545 / 1,
BTTB 2810) Beiwagen VB 02,
Dach grau
(Zeuke ,
BTTB 2812)
br171_vb vb171
BR 171 018-5
Dach grau
(BTTB 2810) Beiwagen BR 171 824-6,
Dach grau
(BTTB 2812)
transius_rt_ws_2tlg
SVT "Courier", 2teilig
rot / weiß
(Zeuke) SVT "Courier", 2teilig
weiß / rot
(Zeuke) SVT "Courier", 2teilig
weiß / blau
(Zeuke 545 / 34)
Die Diesel-Schnelltriebwagen Elektro-Triebzug Fahrtrafo
SVT "Intourex", 3teilig
weiß / blau
(Zeuke 545 / 37)
ET "Transitus", 3teilig, weiß / blau
(Zeuke 545 / 35) ET "Transitus", 3teilig, grün / gelb
(Zeuke 545 / 35)
Mittelwagen für "Courier", Transitus", "Intourex";
rot / weiß
(Zeuke) Mittelwagen für "Courier", Transitus", "Intourex";
weiß / blau
(Zeuke) Mittelwagen für "Courier", Transitus", "Intourex"
weiß / rot
(Zeuke) Mittelwagen für "Courier", Transitus", "Intourex"; grün / gelb
(Zeuke)
e11_022dach_beige.jpg (55398 Byte) e11_022rt.jpg (64664 Byte)
E 11 022, DR
grün, Dach beige
(Zeuke 545 / 754)
E 11 015, DR
grün, Dach grau
(Zeuke 545 / 754,
BTTB) E 11 022, DR
rot
(Zeuke / BTTB 2322)
BR 211 018-7, DR
rot
(BTTB 2322)
e42_018
E 42, DR,
grün, Dach beige
(Zeuke 545 / 755) E 42 018, DR
grün, Dach grau
(Zeuke 545 / 755,
BTTB 2321) BR 242 020-6, DR
grün, Dach grau
(BTTB 2321) BR 242 018-2, DR
grün, Dach grau
(BTTB 2321)
E 70 01, DR, braun
(Zeuke / Herr 545 / 25, 545 / 2 / 2)
E 70 01, DR, grün
beschriftet
(Zeuke / Herr 545 / 24) E 70, DR, grün,
unbeschriftet
(Zeuke / Herr) E 70 01, DR, grau
(Zeuke / Herr)
e94zeuke br254_065_6 br194db
E 94 065, DR, grün
(Zeuke 545 / 751) BR 254 065-6, DR, grün
(BTTB 2410) BR 194 178-0, DB, blau
(BTTB 2411) Reihe 1020 020, ÖBB, rot
(BTTB 2412)
br250
BR 250 112-0, DR, bordeauxrot
(BTTB 2330) BR 250 245-8, DR, hellrot
(BTTB 2331)
e499blau_bttb e499g e499 szd
E 499 035, CSD
blau / elfenbein
(Zeuke 545 / 20,
Zeuke 545 / 752 / 1,
BTTB 2312) E 499 035, CSD
grün / elfenbein
(Zeuke 545 / 21,
Zeuke 545 / 752 / 2
BTTB 2311) YC 1-003, SZD, grün
(BTTB 2313)
E 499, SJ, rotorange
(BTTB)
start_e_lok_blau start_e_lok_gn
2achsige E-Lok
CC 7200, SNCF,
blau mit silberner Zierleiste
(BTTB, aus Start-Set) 2achsige E-Lok
CC 7200, SNCF,
blau ohne Zierleiste
(BTTB, aus Start-Set)
2achsige E-Lok
CC 7200, SNCF,
grün
(BTTB, aus Start-Set)
2achsige E-Lok
CC 7200, SNCF,
hellgrau / gelb als NS-Lok
(BTTB, aus Start-Set)
Cookies
This website uses cookies to improve your experience. We'll assume you're ok with this, but you can opt-out if you wish. Diese Website verwendet Cookies, um Ihre Erfahrung zu verbessern. Wir gehen davon aus, dass Sie damit einverstanden sind, aber Sie können sich abmelden, wenn Sie dies wünschen. Cookie settingsACCEPT
Privacy & Cookies Policy
Privacy Overview
This website uses cookies to improve your experience while you navigate through the website. Out of these cookies, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may have an effect on your browsing experience.
Necessary cookies are absolutely essential for the website to function properly. This category only includes cookies that ensures basic functionalities and security features of the website. These cookies do not store any personal information.
Any cookies that may not be particularly necessary for the website to function and is used specifically to collect user personal data via analytics, ads, other embedded contents are termed as non-necessary cookies. It is mandatory to procure user consent prior to running these cookies on your website.