Moderna, Biontech and Pfizer Corona vaccines – big side effect hope against Covid-19 – today
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After Biontech and Pfizer, the US company Moderna also reports that its corona vaccine is astonishingly effective. This should also protect against severe Covid-19 courses. And there is perhaps a decisive advantage over the competition in terms of logistics. What was unclear for a long time is emerging as an actual way out of the coronavirus pandemic: Just one week after the Mainz-based company Biontech and its partner Pfizer, US competitor Moderna also announced a success with a corona vaccine. The company announced that this had an effectiveness of 94.5 percent. But Moderna also mentions other advantages: such as protection against severe courses and a surprisingly high stability of the preparation at refrigerator temperatures.
Pandemics on the Rise mRNA – The Vaccine for the 21st Century?
Biontech had also stated an effectiveness of more than 90 percent for its vaccine BNT162b2, but without giving further details. Moderna is becoming more precise: Of the around 30,000 participants in the phase 3 study on the mRNA-1273 vaccine, 95 had so far contracted Covid-19. As it turns out, 90 cases occurred in the control group who received a placebo instead of the vaccine. From the group of those vaccinated, however, only five participants fell ill. This results in a protective effect of 94.5 percent. However, the company emphasizes that this value could change by the end of the study. “It doesn’t get any better – 94.5 percent is really excellent,” commented renowned US immunologist Anthony Fauci, according to CNN. “I’ve always said I would be happy with a 75 percent effective vaccine. An ambitious expectation would have been 90 or 95 percent, but we didn’t expect that.” The expert Peter Openshaw from Imperial College London spoke of “exciting” news. They increased “optimism that we will have a selection of good vaccines in the next few months”.
Like Biontech and Pfizer, Moderna is also using an mRNA vaccine – a very new process for which there is still no approved vaccine in the world. It is all the more astonishing that this technology is not only the first to deliver results, but also a surprisingly high level of protection against Covid-19. This confirms that the concept of mRNA “is a useful strategy not only for Covid, but also for threats from future infectious diseases,” said US immunologist Barry Bloom of the New York Times.
“No significant safety concerns”
In addition to being highly effective, Moderna also reports that its mRNA vaccine is well tolerated. There are no significant safety concerns, the press release said. In the study, there were only mild to moderate side effects: including fatigue, muscle, joint or headache as well as pain after the puncture, but each was only “short-lived”. Moderna also provides information on an important question: According to company boss Stéphane Bancel, the vaccine can prevent not only mild but also severe Covid-19 diseases. Among the patients in the study were eleven with severe courses – but they all belonged to the placebo group. Biontech and Pfizer had not released details about the impact of their vaccine on severe disease.
Interview with Biontech founder Sahin: “Vaccine is almost perfect”
However, there are still unanswered questions about the Moderna vaccine. For example, whether the protective effect is equally pronounced in younger and older people. This is of particular importance because older people are particularly at risk of getting seriously ill with Covid-19. In the case of mRNA-1273, too, it is unclear how long the protection by vaccination lasts. Both questions are still unanswered with regard to the Biontech vaccine.
Advantage over Biontech vaccine
Another hurdle for mRNA vaccines: they have to be stored at low temperatures in order to remain stable. While the Biontech vaccine has to be transported at minus 70 degrees to the location of the vaccination, minus 20 degrees are sufficient for the preparation from Moderna, the company said. Because Moderna uses a different recipe for the protective fat globules in which the mRNA is embedded, said Moderna spokesman Ray Jordan according to the “New York Times”. Moderna also announced that the shelf life of its vaccine at refrigerator temperature is longer than expected: namely 30 days at a temperature of two to eight degrees. Previously, a shelf life of seven days was assumed. According to Pfizer, the Biontech vaccine cannot be stored at similar temperatures for more than five days. According to experts, the lower temperature sensitivity of the Moderna vaccine is an advantage in terms of logistics. In the USA, for example, medical practices and pharmacies are equipped to cool vaccines at minus 20 degrees – but not for minus 70 degrees, as required by the Biontech vaccine.
“Actually a waste product” Biontech is attracting billions in sales with vaccine
Moderna now wants – like Biontech and Pfizer – to apply for an emergency approval for its vaccine in the USA in the coming weeks. Applications to the approval authorities in other countries are also planned. 20 million vaccine doses could be ready for delivery in the USA by the end of the year. According to its own information, the company could produce between 500 million and one billion vaccine doses in 2021. So far, there is no vaccine against Covid-19 approved according to Western standards. In China, however, almost half a million people have already been vaccinated with the vaccine from the state biotech company Sinopharm, reported the Wall Street Journal. The Russian Ministry of Health had already approved the “Sputnik V” vaccine on August 11th – according to the interim results of the ongoing phase 3 study, this corona vaccine is 92 percent effective.
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Jedoch startet der kompakte Familienfreund auch schon bei knapp 40.000 Euro. Alle Infos in der Übersicht Tags: suchen suche search tag anzeigen besucherzahl browser design domain finger inhalt jahr karpfen konto liegen materie problem relevanter inhalt schalten spiel tag webseite werbung zugriff Görings Märklin Modelleisenbahn >>> read more
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BR 01, DRG
(BTTB 2120)
BR 23 1003, DR
(Zeuke 159 / 77,
545 / 77) BR 23 1111, DR
(BTTB 2110)
BR 23, DR
(BTTB, aus "Touristen Express"-Set))
br35_1111
BR 35 1111-0, DR
(BTTB 2110)
br56
BR 56 2719, DR
(BTTB 2230) G 8.2, Nr. 2721, KPEV
(BTTB 2231)
br81_013dr_zeuke_schw_rahmen br81_001rt_rahmen_plast br81_004
BR 81 013, DR
(Zeuke 159 / 51,
545 / 51) BR 81 001, DR
(BTTB 2210)
BR 81 004, DRG
(BTTB 2210)
BR 81 004, DB
(BTTB 2211)
BR 81, DR
vereinfachte Steuerung
(Zeuke 159 / 78)
br86_1615_3 br86_460
BR 86 1615-5, DR
(BTTB 2240) BR 86 460, DRG
(BTTB 2242) BR 86 173, DB
(BTTB 2241) Reihe 455, CSD
(BTTB 2244)
br 92 zeuke br 92_6582 bttb_rt_rahmen br92
BR 92 6582, DR
(Zeuke 545 / 494) BR 92 6582, DR
(BTTB 2220) BR 92 als Privatbahn (BTTB
(BTTB, aus Start-Set) BR 92 als Nord-Belge (BTTB, aus Start-Set)
start_tenderlok_schw.jpg (41542 Byte)
2achsige Tenderlok, schwarz
(BTTB, aus Start-Set) 2achsige Tenderlok, grün
(BTTB, aus Start-Set)
v36_071grau v36_071dr_gn
V 36 071, DR, grau
(Zeuke 545 / 23,
BTTB 2631) V 36 071, DR, grün
(Zeuke 545 / 22)
V 36 021, DR, grün
(BTTB 2630)
BR 103 021-2, DR, grün
(BTTB 2630)
br103gelb.jpg (62757 Byte) v36_265db_rt.jpg (56714 Byte)
BR 103 033-7, DR, gelb
(BTTB 2631) V 36 255, DB, rot
(BTTB 2632) V 36, DB, schwarz
(BTTB) Y 50, SNCF, grün
(BTTB 2634)
zeuke_v75 zeuke_t435
V 75 001, 1. Ausführung
DR, rot
(Zeuke 545 / 53) T 435 001,
1. Ausführung
CSD, blau,
weißes Geländer
(Zeuke 545 / 52)
br107_001_0 t435 t435
BR 107 001-0, DR, rot
(BTTB 2620)
T 435 001, CSD, blau
schwarzes Geländer
(BTTB 2621) T 435 040, CSD, blau
weißes Geländer
(BTTB 2621)
ym32_125
YM 32-205 , SZD, grün
(BTTB 2622) YM 32-125; SZD, grün
(BTTB 2622)
br110 br110_156 gelb br212_176_2db_rt
BR 110 034-7, DR, rot
(BTTB 2540) BR 110 156-7, DR, gelb
(BTTB 2545) BR 211 167-2, DB, blau
(BTTB 2546) BR 212 176-2, DB, rot
(BTTB 2547)
v180_146 br118_114_8
V180 160, DR
rot / elfenbein
(Zeuke 545 / 750) V 180 146, DR
rot / elfenbein
(BTTB 2520) BR 118 146-0, DR
rot / creme
(BTTB 2522) BR 118 114-8, DR
rot / creme
(BTTB 2522)
BR 119 120-4, DR
(BTTB 2521)
br130dr
BR 130 007-8, DR
(BTTB 2640) T 679, CSD
(BTTB 2641)
br221rot br221_137_3blau_beige v200ic_rt_beige_rt
V 200 139, DB
rot / grau
(Zeuke 159 / 76,
545 / 26)
BR 221 139-9, DB
rot / silbergrau
(BTTB 2510)
BR 221 137-5, DB
blau / beige
(BTTB 2511)
BR 221, DB
rot / beige
(BTTB 2512)
v200 cccp v200 silverlines
V 200 "CCCP"
silber / rot
(Zeuke ) V 200 "Silver Lines"
silber / blau
(Zeuke ) V 200
braun
(Zeuke, aus Start-Set) V 200, SJ
braun
(BTTB, aus Start-Set)
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T 334, CSD, rot
(Zeuke 545 / 502) T 334 0508, CSD, blau
(Zeuke 545 / 501) T 334, CSD, grün / weiß
(BTTB 2610) MH, DSB, grün
(Zeuke 545 / 503)
t334gn_elf_start2a
T 334, 2achsig
blau / creme
(Zeuke (, aus Start-Set) T 334, 2achsig
grün / elfenbein
(Zeuke
(BTTB, aus Start-Set)
noab_mav_neu noab_dsb_bttb noab_sncb
M 61 001, MAV, weinrot
(Zeuke 545 / 9,
BTTB 2532) M 61 019, MAV, rot
(BTTB 2532)
My 1125, DSB, weinrot
(Zeuke 545 / 8,
BTTB 2531) R 202 003, SNCB, grün
(BTTB 2533)
start_taigatrommel
2achsige Diesellok
ähnlich DR-BR 120, rot
(BTTB, aus Start-Set) 2achsige Diesellok
ähnlich DR-BR 120, grün
(BTTB, aus Start-Set)
vt2_09_dach_beige
VT 2.09.070
Dach beige
(Zeuke)
Beiwagen VB 02,
Dach beige
(Zeuke)
VT 2.09.070 + VB,
Dach grau
(Zeuke 545 / 1,
BTTB 2810) Beiwagen VB 02,
Dach grau
(Zeuke ,
BTTB 2812)
br171_vb vb171
BR 171 018-5
Dach grau
(BTTB 2810) Beiwagen BR 171 824-6,
Dach grau
(BTTB 2812)
transius_rt_ws_2tlg
SVT "Courier", 2teilig
rot / weiß
(Zeuke) SVT "Courier", 2teilig
weiß / rot
(Zeuke) SVT "Courier", 2teilig
weiß / blau
(Zeuke 545 / 34)
Die Diesel-Schnelltriebwagen Elektro-Triebzug Fahrtrafo
SVT "Intourex", 3teilig
weiß / blau
(Zeuke 545 / 37)
ET "Transitus", 3teilig, weiß / blau
(Zeuke 545 / 35) ET "Transitus", 3teilig, grün / gelb
(Zeuke 545 / 35)
Mittelwagen für "Courier", Transitus", "Intourex";
rot / weiß
(Zeuke) Mittelwagen für "Courier", Transitus", "Intourex";
weiß / blau
(Zeuke) Mittelwagen für "Courier", Transitus", "Intourex"
weiß / rot
(Zeuke) Mittelwagen für "Courier", Transitus", "Intourex"; grün / gelb
(Zeuke)
e11_022dach_beige.jpg (55398 Byte) e11_022rt.jpg (64664 Byte)
E 11 022, DR
grün, Dach beige
(Zeuke 545 / 754)
E 11 015, DR
grün, Dach grau
(Zeuke 545 / 754,
BTTB) E 11 022, DR
rot
(Zeuke / BTTB 2322)
BR 211 018-7, DR
rot
(BTTB 2322)
e42_018
E 42, DR,
grün, Dach beige
(Zeuke 545 / 755) E 42 018, DR
grün, Dach grau
(Zeuke 545 / 755,
BTTB 2321) BR 242 020-6, DR
grün, Dach grau
(BTTB 2321) BR 242 018-2, DR
grün, Dach grau
(BTTB 2321)
E 70 01, DR, braun
(Zeuke / Herr 545 / 25, 545 / 2 / 2)
E 70 01, DR, grün
beschriftet
(Zeuke / Herr 545 / 24) E 70, DR, grün,
unbeschriftet
(Zeuke / Herr) E 70 01, DR, grau
(Zeuke / Herr)
e94zeuke br254_065_6 br194db
E 94 065, DR, grün
(Zeuke 545 / 751) BR 254 065-6, DR, grün
(BTTB 2410) BR 194 178-0, DB, blau
(BTTB 2411) Reihe 1020 020, ÖBB, rot
(BTTB 2412)
br250
BR 250 112-0, DR, bordeauxrot
(BTTB 2330) BR 250 245-8, DR, hellrot
(BTTB 2331)
e499blau_bttb e499g e499 szd
E 499 035, CSD
blau / elfenbein
(Zeuke 545 / 20,
Zeuke 545 / 752 / 1,
BTTB 2312) E 499 035, CSD
grün / elfenbein
(Zeuke 545 / 21,
Zeuke 545 / 752 / 2
BTTB 2311) YC 1-003, SZD, grün
(BTTB 2313)
E 499, SJ, rotorange
(BTTB)
start_e_lok_blau start_e_lok_gn
2achsige E-Lok
CC 7200, SNCF,
blau mit silberner Zierleiste
(BTTB, aus Start-Set) 2achsige E-Lok
CC 7200, SNCF,
blau ohne Zierleiste
(BTTB, aus Start-Set)
2achsige E-Lok
CC 7200, SNCF,
grün
(BTTB, aus Start-Set)
2achsige E-Lok
CC 7200, SNCF,
hellgrau / gelb als NS-Lok
(BTTB, aus Start-Set)
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