Accidental discovery – Covid-19 antibodies dock incorrectly

Samoa

Four out of five Covid-19 patients also suffer from neurological symptoms. Researchers all over the world are wondering how these special symptoms come about. Tests with rodents could now provide a plausible explanation. When it comes to the question of how neurological symptoms and damage arise from a Covid-19 disease, there have so far been several explanations, ranging from a “silent” infection to a sequela of the Sars CoV-2 infection. Most researchers, however, seem to be clear that Sars-CoV-2 does not behave like many other viruses.

For prevention or sick people First laboratory success with antibody vaccination

On the one hand, direct virus damage to the brain is rare in Covid 19 patients. On the other hand, four out of five Covid-19 patients who have to be treated in the hospital complain of neurological symptoms such as muscle pain and headaches or dizziness. Smell and taste disorders are also common among Covid 19 infected people. In addition, there are a number of seriously ill Covid 19 patients who have what is known as encephalopathy, i.e. a pathological change in the brain.

Dizziness and loss of taste neuro-symptoms much more common than thought

Researchers from the German Center for Neurodegenerative Diseases (DZNE) and the Charité-Universitätsmedizin Berlin could now provide an explanatory approach that they discovered by chance. Originally, the teams around Jakob Kreye set out to find effective antibodies that could be used to achieve passive immunization. To do this, almost 600 different antibodies were isolated from the blood plasma of ten Covid 19 patients and then injected into hamsters. In this way, the researchers wanted to find out which antibodies show the greatest healing or protective effect. The researchers were not only able to identify ten very promising antibodies, they also saw a further effect, as they write in a scientific paper that was published in the specialist journal Cell.

Evidence in dead encephalitis is indirect Covid consequence

In order to further investigate the effect of the numerous antibodies, additional tests were carried out on tissue samples from mice. The researchers saw that some antibodies not only bind directly to the virus in order to switch it off, but also to the body’s own structures such as the heart muscle or blood vessels. There were also non-specific antibodies that attached themselves to tissues in the brain. These rather immature antibodies could be the cause of neurological disorders in Covid-19 patients. All antibodies that showed these properties were excluded by the scientists when developing passive immunization. In further research, one must now examine whether the associated tissue could possibly become targets of attacks by one’s own immune system, explains Harald Prüß, who also worked on the study.

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