New Videos - press link here

37719

Two potential drugs — how Corona attacks the heart — today

Biden win election 2020

- Data Covid-19 USA -    World | Coro­na News | Break­ingnews | Tech­nol­o­gy | Sport | Gam­ing | Per­sons | Lifestyle | Pic­tures | Videos | Down­load | Upload | Nat­ur­al | Busi­ness | Shop | Healt | Forums |


Images or Post and Videos — press here

In lab­o­ra­to­ry tests, a team from the Ger­man Cen­ter for Car­dio­vas­cu­lar Research shows that the virus­es can also pen­e­trate cells and mul­ti­ply there. Because they can clear­ly see the mech­a­nisms, the researchers also con­clude that there are two pos­si­ble treat­ment meth­ods. prob­lems are repeat­ed­ly found in patients suf­fer­ing from Covid-19. As ear­ly as July, researchers at the Uni­ver­si­ty Med­ical Cen­ter Ham­burg-Eppen­dorf (UKE) found out that the coro­n­avirus can infect cells and mul­ti­ply in them. A work­ing group from the Ger­man Cen­ter for Car­dio­vas­cu­lar Research has now shown the infec­tion takes place on car­diac mus­cle cells. Their results have been pub­lished in the jour­nal Car­dio­vas­cu­lar Research. To this end, mus­cle cells were first gen­er­at­ed from stem cells that have not yet been assigned to a spe­cif­ic tis­sue type. These were then treat­ed with iso­lat­ed virus mate­r­i­al from the first Ger­man patient who had returned to Ger­many from Wuhan, Chi­na, in March. The cells took up the virus, the virus RNA mul­ti­plied and the virus-typ­i­cal spike pro­tein was also formed.

In order to repro­duce the heart more close­ly, the researchers built small clumps of cells from heart mus­cle cells, blood ves­sel cells and con­nec­tive tis­sue cells. They also detect­ed the spike pro­tein in this. Sars-CoV2 could also mul­ti­ply in real human heart tis­sue. Over­all, how­ev­er, the exper­i­ments sug­gest­ed that heart cells are slight­ly less sus­cep­ti­ble to the virus than oth­er cell types. The rate of cell death trig­gered by the infec­tion was there­fore low­er and it also took a lit­tle longer for the heart cells to die. The experts also observed the “heart­beat” of the twitch­ing heart cells in the test tube. “The cells get real­ly stressed when they are exposed to the virus. The so-called ‘beat­ing rate’ only increas­es sharply and falls after three days because the cells die,” says Ste­fanie Dim­mel­er, who coor­di­nat­ed the exper­i­ments Com­mu­ni­ca­tion from Goethe Uni­ver­si­ty Frank­furt cit­ed.

Anoth­er gate­way

Appar­ent­ly the virus fol­lows a slight­ly dif­fer­ent mech­a­nism in heart cells than in lung cells, for exam­ple. Heart mus­cle cells do not have the mem­brane pro­tein TMPRSS2, which the coro­n­avirus needs in lung cells in addi­tion to the ACE2 recep­tor in order to pen­e­trate the cells. In heart mus­cle cells it uses anoth­er pro­tein, cathep­sin.

Experts: Sick peo­ple avoid clin­ics Fear of coro­na could be fatal

This already results in treat­ment options. Because active sub­stances that inhib­it this pro­tein, so-called cathep­sin inhibitors, suc­cess­ful­ly stopped the virus from mul­ti­ply­ing in the heart mus­cle cells in the lab­o­ra­to­ry tests. The drug Remde­sivir, which is already used for coro­na ther­a­py, was also appar­ent­ly able to pre­vent the pathogen from mul­ti­ply­ing. It is still unclear whether this can also be used in acute ther­a­py. “The heart mus­cle cells are nor­mal­ly well pro­tect­ed because the virus first has to pen­e­trate the vas­cu­lar bar­ri­er. In order to exam­ine the virus infes­ta­tion of the heart in the human body in the acute phase, we would have to take reg­u­lar biop­sies from the heart of sick peo­ple, which is almost impos­si­ble,” says Dim­mel­er . How­ev­er, one could try to treat coro­na patients with prob­lem­at­ic heart reac­tions with cathep­sin inhibitors.

Press me - I want to write a comment here! - press me


Last Feeds of US

Hotel lets couple stay for free on Valentine’s Day for 18 years after they conceived on the holiday

Miley Cyrus says she was told to ‘cover it so I went the other way’ as she poses topless for Rolling Stone

Biden Addresses ‘Stalling’ Economy Amid New Hopes on Stimulus

How 700 Epidemiologists Are Living Now, and What They Think Is Next

Biden on Trump administration distributing vaccine: ‘There is no detailed plan’ — CNN


Irland

14 Best WordPress SEO Plugins and Tools That You Should Use

Often we’re asked about what are the best WordPress SEO plugins and tools that we recommend. That’s because search engines ...
Read More
Biden

Turkey imposes Corona curfew on weekends — today

For people in Turkey, nationwide curfews apply immediately on weekends due to corona. On Saturdays and Sundays, people are only ...
Read More
symptoms of Corona Covid-19

Bay Area experiences “gloomy Covid winter” — today

For millions of Californians in the San Francisco area, stricter requirements will apply from Sunday due to rising corona numbers ...
Read More
DT-Face

Portugal extends Corona state of emergency — today

Portugal has extended its Corona emergency by two weeks to December 23. Parliament approved a proposal from President Marcelo Rebelo ...
Read More

All Categorys

Absentee Voting Appointments and Executive Changes Arizona Armenia Army Aviation Azerbaijan BAE Systems Barr, William P Barrett, Amy Coney Biden, Joseph R Jr Black People Breaking Centers for Disease Control and Prevention China Clinical Trials Computers and the Internet Conservatism (US Politics) Coronavirus (2019-nCoV) Coronavirus Aid, Relief, and Economic Security Act (2020) Coronavirus Covid-19 Coronavirus Reopenings Coronavirus Risks and Safety Concerns Debates (Political) Democratic Party Deutschland Disease Rates Donald Trump drone Drugs (Pharmaceuticals) Elections, House of Representatives Elections, Senate F-35 Fashion fighter Florida France future Georgia Germany Harris, Kamala D helicopter Israel Italia Justice Department Labor and Jobs Lockheed Martin Marines Maritime Security Masks Michigan missile Nagorno-Karabakh Navy News news archive e check auto New York City Pence, Mike Pennsylvania Pfizer Inc Photo Plugins Politics and Government Polls and Public Opinion Presidential Election of 2016 Presidential Election of 2020 Presidential Transition (US) Press Releases Quarantines Republican Party Rumors and Misinformation Russia Second Breaking Senate Senate Committee on the Judiciary Shutdowns (Institutional) Sony Playstation 5 States (US) Supreme Court (US) tank Trump, Donald J Trump Administration Trump Coronavirus Positive Result UK Ukraine United States United States Economy United States International Relations United States Politics and Government USA USAF Vaccination and Immunization veterans-us Video Videos-in Voter Fraud (Election Fraud) Voting and Voters White House White House Coronavirus Outbreak (2020) your-feed-healthcare